2016 issue 1


Volume 32, issue 1

Original article

Wpływ terapii elektrowstrząsowej w depresji lekoopornej na stężenie czynnika neurotrofowego pochodzenia mózgowego (BDNF) / The effect of electroconvulsive therapy in drug-resistant depression on serum level of the brain-derived neurotrophic factor (BDNF)

Krystian J. Wiśniewski1, Miłosz Krzywotulski1, Maria Skibińska2, Alicja Bartkowska-Śniatkowska3, Maria Chłopocka-Woźniak1, Janusz Rybakowski1
1. Uniwersytet Medyczny w Poznaniu, Klinika Psychiatrii Dorosłych
2. Uniwersytet Medyczny w Poznaniu, Zakład Genetyki w Psychiatrii
3. Uniwersytet Medyczny w Poznaniu, Klinika Anestezjologii i Intensywnej Terapii Pediatrycznej
Farmakoterapia w Psychiatrii i Neurologii 2016, 32 (1), 27–32
Date of publication: 08-04-2016
DOI: http://dx.medra.org/10.17393/fpn.2016.03.001
Keywords: electroconvulsive therapy, brain-derived neurotrophic factor, BDNF, drug-resistant depression


Objectives. Electroconvulsive therapy (ECT) causes an increased neurogenesis and the brain-derived neurotrophic factor (BDNF) is important for neuronal survival. Many studies have shown, that, in depression, BDNF level is decreased, and that ECT can cause its increase. To investigate whether such a relationship occurs in drug-resistant depression (DRD), the purpose of this study was an assessment of the effect of ECT on serum BDNF level in patients with DRD.

Material and methods. The study was performed on 58 patients with DRD, 25 male, 33 female, aged 56 ±13 (mean ± SD), treated with ECT in 2013–2014. In 35 patients, all ECT sessions were performed with thiopental anesthesia (dosed 2–5 mg/kg). In 11 patients, ketamine was used as an anesthetic for 2nd and 3rd session (dosed 1.0–1.5 mg/kg), and in 12 patients, for sessions 2nd, 4th, 6th, 8th, and 10th (dosed 1.0–1.5 mg/kg). Serum BDNF levels were determined in the morning, before 1st session and after 7, 14 and 21 days of the ECT treatment.

Results. The levels of BDNF did not show significant differences in the course of ECT. This pertained to the whole group, male and female groups, recurrent depression and bipolar disorder groups, aged less than and above 55 years, with less than and above 30 points in the Hamilton Depression Rating Scale, and undergone thiopental anesthesia only or two modes of thiopental interchanged with ketamine.

Conclusions. Obtained results indicate, that, in patients with DRD, which had received antidepressant and mood-stabilizing treatment, despite improvement in psychiatric status in the course of ECT, no significant changes in BDNF level were observed.

Address for correspondence:
Uniwersytet Medyczny w Poznaniu
Klinika Psychiatrii Dorosłych
ul. Szpitalna 27/33, 60-572 Poznań, Poland
phone: +48 792 223 757
email: kwis85@gmail.com