For almost 30 years, statins have been widely used in primary and secondary prevention of cardiovascular diseases. In addition to the lipid lowering effect, they also exhibit anti-inflammatory, antioxidant and neurotrophic activities, which may be important in the treatment and prevention of depression. Reports on the relationship between the use of statins and depression are contradictory. Many clinical trials have showed no effect of statins on mood and some of them have revealed the antidepressant effect of these drugs, especially in patients with cardiovascular diseases. The increased risk of depression was rarely observed in patients taking statins.