2014 issue 3-4


Volume 23, issue 3-4

Review article

Why patients taking antipsychotics gain weight?

Adam Wysokiński1, Tomasz Sobów2
1. Uniwersytet Medyczny w Łodzi, Klinika Psychiatrii Wieku Podeszłego i Zaburzeń Psychotycznych
2. Uniwersytet Medyczny w Łodzi, Zakład Psychologii Lekarskiej
Farmakoterapia w Psychiatrii i Neurologii, 2014, 3–4, 177–190
Keywords: metabolic syndrome, schizophrenia, antipsychotics, weight gain, appetite


Over the last few years psychiatrists have been increasingly concerned about obesity, dyslipidemia and raised glucose levels in patients taking antipsychotics. The problem of metabolic syndrome is significantly more frequent (up to 2‒3 times) in this group of patients. In this paper, we have presented a summary of the mechanisms responsible for increased appetite and weight gain induced by antipsychotics. These two phenomena underlie further metabolic abnormalities. Due to high prevalence of metabolic disorders and their effect on increased cardiovascular risk, the systemic evaluation of basic risk factors (abdominal obesity, cholesterol, triglycerides and glucose, blood pressure) is necessary in all patients taking antipsychotics (the same applies to antidepressants and mood stabilizers).

Address for correspondence:
Adam Wysokiński
Uniwersytet Medyczny w Łodzi
Klinika Psychiatrii Wieku Podeszłego i Zaburzeń Psychotycznych
ul. Czechosłowacka 8/10, 92-216 Łódź, Polska
e-mail: adam.wysokinski@umed.lodz.pl
phone: +48 609 676 178