2014 issue 3-4


Volume 23, issue 3-4

Review article

Role of ceruloplasmin in neurodegenerative disorders

Mariola Wolanin1, Bożena Kłysz1, Anna Członkowska1
1. Institute of Psychiatry and Neurology, Second Department of Neurology, Warsaw, Poland
Farmakoterapia w Psychiatrii i Neurologii, 2014, 3–4, 159–176
Keywords: ceruloplasmin, iron, neurodegenerative disorders, free radicals, antioxidants


Ceruloplasmin is the main protein involved in copper metabolism. Ceruloplasmin plays a significant role in iron metabolism; it facilitates oxidation ferrous ion to ferric ion and encourages binding ferric ion to transferrin and ferritin. Taking into account its iron oxidase activity, ceruloplasmin belongs to a ferroxidases subclass.
Ceruloplasmin activity is decreased in many neurodegenerative disorders: aceruloplasminemia, Alzheimer’s disease and Parkinson’s disease. This observation coexists with iron (ferric ion) deposits in many organs. In Alzheimer’s disease, Parkinson’s disease and aceruloplasminemia ferric ion accumulation results in apoptosis on free radicals damage pathway. In Wilson’s disease, impaired intracellular copper transport results in low serum ceruloplasmin and tissue copper accumulation. All periods of mechanisms of damages of cells have not been explained so far. Further research is essential concerning the damage to free radicals neurons in neurodegenerative diseases and possible ways of treatment.

Address for correspondence:
Mariola Wolanin
Instytut Psychiatrii i Neurologii
II Klinika Neurologiczna
ul. Sobieskiego 9, 02-957 Warszawa, Poland
e-mail: mwolanin@ipin.edu.pl