2005 issue 2


Volume 21, issue 2


Procognitive influence of moclobemide in vascular depression

Alina Borkowska1, Ilona Pietrzak1, Janusz Rybakowski1
1. Zakład Neuropsychologii Klinicznej CM UMK w Bydgoszczy Klinika Psychiatrii Dorosłych AM w Poznaniu
Farmakoterapia w Psychiatrii i Neurologii, 2005, 2, 167-173
Keywords: vascular depression, moclobemide, cognitive dysfunctions


Clinical assessment and neuropsychological tests measuring working memory were performed in 23 patients with depression secondary to cerebrovascular changes, before and after three-month treatment with moclobemide. Before treatment, significant global cognitive deficit and working memory disturbances were found in all investigated patients. Treatment with moclobemide resulted in an improvement of depressed symptoms and cognitive functions. The improvement of performance on neuropsychological tests, except for Stroop test B, did not show correlation with the level of improvement of depressed symptoms.