2005 issue 2


Volume 21, issue 2


Neurophysiological mechanisms of addiction: the role of impulsive behavior

Wojciech Kostowski1
1. Zakład Farmakologii i Fizjologii Układu Nerwowego Instytut Psychiatrii i Neurologii w Warszawie
Farmakoterapia w Psychiatrii i Neurologii, 2005, 2, 93-102
Keywords: impulse control, addiction, serotonine


Increasing evidence suggests that impulsivity may play an important role in the mechanism of the central nervous system disorders including drug abuse. Clinical studies suggest that patients with increased aggresivity and persons who commit suicide as well as drug abusers show increased impulsivity. Likewise, animal laboratory studies show correlation between drug-seeking and impulsive behavior. Based on animal and clinical studies suggesting that brain serotonergic system plays a critical role in the regulation of impulse-control mechanism, it seems possible that dysfunction of serotonergic neurotransmission contributes to the drug addiction.