In this paper a case of 55-years male patient who suffered from urinary hesitancy, weak urinary stream, and a filling of incomplete emptying after administration of 150 mg of venlafaxine due to depressive episode was reported. The careful urologic examination confirmed the diagnosis of benign prostatic hyperplasia with asymptomatic course before the onset of treatment with venlafaxine. These symptoms disappeared after switching an antidepressant therapy to selective serotonin reuptake inhibitor. The possible mechanisms responsible for urinary hesitancy in the course of treatment with venlafaxine were discussed. The appearance of urinary hesitancy in male patients treated with noradrenergic antidepresive drugs is the indication for careful urologic evaluation to rule out or confirm the prostatic disease.