Abstract
Twenty-four depressive patients (25 treatment modalities) were evaluated to estimate an effectiveness of combining treatment with antidepressant and pindolol. That group included also 14 treatment-resistant patients. As the results had indicated pindolol augmentation significantly reduced total scores in Hamilton Depression Rating Scale vs. baseline. That effect was not seen after 7 day of treatment. Pindolol augmentation was more effective when used with tricyclics than with serotonin selective reuptake inhibitors, but small number of patients may have an influence of that result. Combined treatment had good tolerability, although phase change from depression to mania was observed as well.