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Volume 37, issue 3

Case report

Obsessive compulsive syndrome in a patient treated by cariprazine in the course of schizophrenia with predominantly negative symptoms

Agnieszka Koźmin-Burzyńska1, Maciej Matuszczyk2, Marek Krzystanek1
1. Department and Clinic of Psychiatric Rehabilitation, Faculty of Medical Sciences, Medical University of Silesia in Katowice
2. Centrum Zdrowia Psychicznego Tychy, Medforum Sp. z o.o.
Farmakoterapia w Psychiatrii i Neurologii 2021, 37 (3-4): 259-266
Date of publication: 28-04-2022
DOI: https://doi.org/10.5114/fpn.2021.115645
Keywords: cariprazine, negative symptoms, obsessive-compulsive symptoms, schizophrenia

Abstract

Objectives. The negative symptoms of schizophrenia pose a significant problem for both the patients and their surroundings, leading to impaired daily functioning. It is also a diagnostic and therapeutic challenge. A co-occurrence of obsessive-compulsive symptoms in the course of schizophrenia is a challenge in the selection of appropriate pharmacotherapy.

Case report. The following case study presents a gradual metamorphosis of symptoms and a way of functioning in a patient with a predominance of negative symptoms in schizophrenia under the influence of cariprazine, and the disclosure of previously unobserved thoughts and obsessive activities after modification of pharmacotherapy. The presented clinical case indicates that cariprazine is effective in the treatment of negative symptoms of schizophrenia and may cause secondary obsessive-compulsive symptoms.

Conclusions. In the case discussion, the authors point out that the possibility of obsessive-compulsive symptoms may relate to a group of antipsychotic drugs with antiserotonin activity.

Address for correspondence:
Agnieszka Koźmin-Burzyńska
Klinika Rehabilitacji Psychiatrycznej
Katedra Psychiatrii Dorosłych
Śląski Uniwersytet Medyczny
w Katowicach
45/47 Ziołowa Str.
40-635 Katowice, Poland
email: kozminburzynska@gmail.com