The aim of this paper is to review the literature regarding a new method of the treatment of depression, in which a single dose of botulinum neurotoxin A is injected into the glabellar lines. The authors discuss the structure and mechanism of the effect of botulinum, along with the risk and symptoms of poisoning and the applications of botulinum in medicine. Five publications are reviewed, one of them involving a series of case studies and four reporting on clinical trials, in which botulinum A was administered to patients with moderate or severe depression. All trials demonstrate a significant antidepressive effect of botulinum A, injected in the glabellar region. This allows for the conclusion that botulinum A injection in the glabellar region is an effective and durable treatment for depression.