2016 issue 3


Volume 32, issue 3

Review article

Antidepressive effect of botulinum neurotoxin injection

Marek Krzystanek1, Roman Wojnar1, Rafał Skowronek2, Ewa Martyniak1, Artur Pałasz3
1. Śląski Uniwersytet Medyczny, Katedra Psychiatrii i Psychoterapii, Klinika Rehabilitacji Psychiatrycznej, Katowice
2. Śląski Uniwersytet Medyczny, Katedra Medycyny Sądowej i Toksykologii Sądowo-Lekarskiej, Katowice
3. Śląski Uniwersytet Medyczny, Katedra Histologii i Embriologii, Zakład Histologii, Katowice
Farmakoterapia w Psychiatrii i Neurologii 2016, 32 (3), 171–180
Date of publication: 21-11-2016
DOI: http://dx.medra.org/10.17393/fpn.2016.08.001
Keywords: botulinum neurotoxin A, depression, treatment of depression


The aim of this paper is to review the literature regarding a new method of the treatment of depression, in which a single dose of botulinum neurotoxin A is injected into the glabellar lines. The authors discuss the structure and mechanism of the effect of botulinum, along with the risk and symptoms of poisoning and the applications of botulinum in medicine. Five publications are reviewed, one of them involving a series of case studies and four reporting on clinical trials, in which botulinum A was administered to patients with moderate or severe depression. All trials demonstrate a significant antidepressive effect of botulinum A, injected in the glabellar region. This allows for the conclusion that botulinum A injection in the glabellar region is an effective and durable treatment for depression.

Address for correspondence:
Marek Krzystanek
Klinika Rehabilitacji Psychiatrycznej
Katedra Psychiatrii i Psychoterapii
ul. Ziołowa 45, 40-635 Katowice
phone: +48 32 205 92 60
email: krzystanekmarek@gmail.com