Doksylamine is the inquiring proposal, facing the limited number of the safe and effective sedative and sleeping drugs. Doxylamine belongs to the first-generation H1-antihistamine group. It shows sedative, sleep-inducing, antiemetic and anti-allergic effect.
The aim of the article was to compare doxylamine with other sleeping pills and tranquilizers. The detailed research was performed to investigate effectiveness and tolerance of doxylamine in the treatment of insomnia and anxiety. The potency of the sedative effect of doxylamine, flunitrazepam and fenobarbital are comparable, but doxylamine does not cause addiction. Numerous studies prove the effectiveness and safety of doxylamine in the short-term treatment of insomnia. The safety of doxylamine in pregnancy was also proven. The therapeutic index of doxylamine is wide, and its potential side effects are usually mild and transient. Most common adverse effects are daytime sleepiness and dry mouth.
The collected data indicate the doxylamine as an alternative to sleep-inducers and tranquilizers.