2015 issue 3-4

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Volume 31, issue 3-4

Original article

Cytokiny IL-2, IL-4, IL-6, IL-8 i IL-10 u młodzieży i młodych dorosłych ze spektrum choroby afektywnej dwubiegunowej – badania wstępne / Cytokines IL-2, IL-4, IL-6, IL-8 and IL-10 in adolescents and young adults with bipolar spectrum – preliminary results

Aleksandra Rajewska-Rager1, Monika Dmitrzak-Węglarz2, Maria Skibińska2, Natalia Lepczyńska3, Jacek Sikora4
1. Uniwersytet Medyczny im. K. Marcinowskiego w Poznaniu, Katedra Psychiatrii, Klinika Psychiatrii Dorosłych
2. Uniwersytet Medyczny im. K. Marcinowskiego w Poznaniu, Katedra Psychiatrii, Zakład Genetyki w Psychiatrii
3. Uniwersytet Medyczny im. K. Marcinowskiego w Poznaniu, Klinika Psychiatrii Dzieci i Młodzieży
4. Uniwersytet Medyczny im. K. Marcinowskiego w Poznaniu, Katedra Biologii i Ochrony Środowiska, Zakład Immunobiochemii
Farmakoterapia w Psychiatrii i Neurologii 2015, 31 (3–4), 221–227
Date of publication: 26-02-2016
DOI: http://dx.medra.org/10.17393/fpn.2016.02.001
Keywords: cytokines, neuroimmunology, bipolar disorder spectrum, mood disorder at youth

Objectives. In recent years, growing interest in neuroimmunology of affective disorders is observed. Changes in concentrations of cytokines may be a potential biomarker in mood disorders. However, despite the numerous studies in adults, there have been few studies of assessment cytokines levels in young patients with bipolar disorder. The purpose of this study was to assess selected cytokines in serum of adolescents and young adults diagnosed with mood disorders in various episodes of the disease.

Material and methods. The study included 33 young people aged 14–24 with a diagnosis of mood disorders on the spectrum of bipolar disorder. The diagnosis was carried out in accordance with the diagnostic criteria of ICD-10 and DSM-IV by two independent psychiatrists, using structured interviews (KSADS-PL, SCID). Clinical evaluation (Beck, HAMD, YADRS, HCL-32) and biochemical analysis was conducted during control subsequent visits (visit 0, week 12, month 6).

Results. The results showed a statistically significant correlation between the lack of depression symptoms and higher concentrations of interleukin-8 in the 12th week of the study (p = 0,017). However, the 6th month of the study revealed a higher concentration of Interleukin-6 in the subset of young adults (18 > years) compared to teenagers (p = 0.030). In the 6th month of the study, significant relationship was present between the change of diagnosis (into the direction of bipolar disorder) and the occurrence of higher concentrations of interleukin-8 in blood serum (p = 0.033).

Conclusions. Preliminary results suggest that cytokines levels may be a promising indicator for bipolar disorder in youth, although replication studies with a control group are required.

Address for correspondence:
Uniwersytet Medyczny im. K. Marcinowskiego w Poznaniu
Klinika Psychiatrii Dorosłych
ul. Szpitalna 27/33, 62-170 Poznań, Polska
phone: +48 618 491 450
email: rajrager@ump.edu.pl