This review paper discusses the relationship between cholesterol metabolism and the incidence of neurodegenerative disorders. It also describes the mechanisms of central action of statins. Based on the current literature review, it presents data regarding potential use of statins in Alzheimer's disease, Parkinson's disease and in multiple sclerosis. Most of the studies conducted to date indicate that statins may reduce the risk of Alzheimer's disease. In the case of Parkinson's disease, primary results were not conclusive. The usefulness of statins in the treatment of multiple sclerosis must be confirmed in further clinical trials.