Trazodone is an antidepressant compound with antagonist 5-HT2 and serotonine transporter properties. It is metabolized by cytochrome CYP3A4. Fluconazole is an antifungal medication and it is characterized by biotransformation by the same cytochrome CYP3A4. The drug-drug interaction between both compounds may increase trazodone efﬁ cacy/toxicity by decreasing trazodone metabolism and clearance.
Case description. An 42-years old men treated systematically with trazodone 150 mg took 1 dose of 100 mg of ﬂ uconazole. The somnolence, fatigue, attention problems and changes in subjective perceiving of speed while driving a car occurred that led to some dangerous trafﬁ c situations.
Connclusion. This description suggest drug-drug interaction between trazodone and ﬂuconazole based on the biotransformation by the same cytochrome CYP3A4. Moreover the interaction was potentially dangerous in the context of daily activities that is driving a car in this case.