2010 issue 3-4


Volume 26, issue 3-4

Review article

Pharmacotherapy of personality disorders- review of the pharmacological trials and experts’ guidelines

Justyna Holka-Pokorska1
1. III Klinika Psychiatryczna Instytutu Psychiatrii i Neurologii w Warszawie
Farmakoterapia w Psychiatrii i Neurologii, 2010, 3-4, 149–164
Keywords: pharmacotherapy, personality disorders, guidelines


There is a substantial growth of the amount of data showing the possibility of the recovery during the personality disorder therapy. Other research shows that severness of disorder symptoms change with patient's age. It is also known that psychotherapy as a main therapeutic tool has a strong unprecedented position in the clinical psychiatry. In clinical treatment however patients with personality disorders are treated with pharmacotherapy very often. The majority of clinical models concerning the personality disorders pharmacotherapy are based on the assumption that for patients with abnormal personality structure the pharmacotherapy plays the protective role in case of the decompensation towards the mental disorder symptoms.
The purpose of the article is the description of the most common opinions and recommendations concerning pharmacological treatment of personality disorders with the crucial role of the recommendations of the World Federation of Societies of Biological Psychiatry. The most important placebo controlled research on the effectiveness of various medications during the personality disorder treatments has also been reviewed.

Address for correspondence:
Justyna Holka-Pokorska
III Klinika Psychiatryczna
Instytut Psychiatrii i Neurologii
ul. Sobieskiego 9, 02-957 Warszawa
tel. +48 22 45 82 689, fax. +48 22 45 82 510
e-mail: pokorska@ipin.edu.pl