2010 issue 1


Volume 26, issue 1

Review article

Physiological mechanisms of appetite regulation and pharmacological prophylaxis of olanzapine-induced obesity

Marek Krzystanek1, Artur Pałasz2, Irena Krupka-Matuszczyk1, Ryszard Wiaderkiewicz2, Marcin Kamiński2
1. Katedra i Klinika Psychiatrii i Psychoterapii Śląskiego Uniwersytetu Medycznego w Katowicach
2. Katedra Morfologii, Zakład Histologii Śląskiego Uniwersytetu Medycznego w Katowicach
Farmakoterapia w Psychiatrii i Neurologii, 2010, 1, 29-38
Keywords: appetite regulation, body weight gain, olanzapine


Neuroleptic treatment increases a risk of body weight gain. It seems the risk is highest during clozapine and olanzapine treatment. Body mass gain is shown in 57-58% of patients treated with olanzapine. Mechanisms of body mass gain, accompanying neuroleptic treatment are not fully understood and require further research.
Authors aimed at review of knowledge about appetite regulation and potential mechanisms of body weight gain with the special regard to olanzapine. Summary of pharmacological methods of prophylaxis and treatment of appetite increase, accompanying neuroleptic treatment is also presented.
Analysis of contemporary knowledge indicates that so for there is no convincing evidence of potential difference in an influence of orally dissolving pills and standard oral tablets forms of olanzapine on body weight gain. In relation to confirmed beneficial effect, correcting the orectic influence of olanzapine, further studies on metformin, topiramate, reboxetine and aripiprazole and perhaps on nizatidine and amantadine are necessary.

Address for correspondence:
Marek Krzystanek
Katedra i Klinika Psychiatrii i Psychoterapii
Śląski Uniwersytet Medyczny
ul. Ziołowa 45/47, 40-635 Katowice
tel/fax 032 2059260
e-mail: krzystanekmarek@gmail.com