2010 issue 1


Volume 26, issue 1

Only for Pharmacotherapy in Psychiatry and Neurology

Hyperhomocysteinemia in mental disorders

Agnieszka Permoda-Osip1, Janusz Rybakowski1
1. Klinika Psychiatrii Dorosłych Uniwersytetu Medycznego im. K. Marcinkowskiego w Poznaniu
Farmakoterapia w Psychiatrii i Neurologii, 2010, 1, 7-13
Keywords: homocysteine, affective disorders, dementia, cognitive functions


Increased level of homocysteine is the cause of arteriosclerosis, vascular disorders, neurodegenerative diseases and mental disorders. This paper presents current views on hyperhomocysteinemia and its pathogenic role in mental disorders. The homocysteine metabolism is described as well as the influence of various factors on it, and also the pathomechanism of alterations resulting from an increased level of homocysteine. There is also a focus on genetic disorders leading to increased level of homocysteine and its correlation with mental disorders and dementia. The multidirectional influence of hyperhomocysteinemia on cardiovascular, immune and neurotransmitter systems is described as well as a neurotoxic action of homocysteine. Complex correlations between vitamin deficiency and hyperhomocysteinemia with depression, cognitive functions impairment and dementia are also presented. Oral supplementation with B-group vitamins and folic acid can significantly decrease a level of homocysteine in blood serum.

Address for correspondence:
Agnieszka Permoda-Osip
Klinika Psychiatrii Dorosłych
Uniwersytet Medyczny
ul. Szpitalna 27/33, 60-572 Poznań
tel. (61) 8475087, fax. (61) 8480392
e-mail: a.a.p@wp.pl