Movement disorders constitute a main issue in the Parkinson’s Disease (PD). They may be considered as an expression of the disease, as well as a side effect of the levodopa treatment, which was refl ected in the diagnosis criteria. A clear response to levodopa and occurrence of dyskinesias related to its application are recognized as typical syndromes of this disease. Movement disorders occurring after the levodopa treatment is connected with the central and peripherial mechanisms. Central mechanisms include progression of nigrostratial degeneration, changes in the dopaminergic receptors and levodopa impact. Peripherial mechanisms are related to absorption and levodopa mechanism. The purpose of therapeutical procedure in PD is the reduction of clinical syptoms and undesired effects of the applied pharmacotherapy.