Volume 22, issue 3-4
Review article
Endocrine and metabolic side-effects of lithium
Dominik Strzelecki1
1. Klinika Zaburzeń Afektywnych, Psychotycznych i Psychiatrii Młodzieżowej Centralnego Szpitala Klinicznego Uniwersytetu Medycznego w Łodzi
Farmakoterapia w Psychiatrii i Neurologii, 2006, 3–4, 159–166
Keywords: lithium, hypothyroidism, hyperthyroidism, hyperparathyroidism, diabetes mellitus, diabetes insipidus, weight gain
Abstract
During lithium treatment appear several significant hormonal changes, which can cause worsening of mental and physical state. Most frequent disorders concern thyroid gland – often diagnosed hypothyreosis, sporadically hyperthyreosis. Other serious adverse effects of lithium treatment are hyperparathyreosis and metabolic disturbances: diabetes mellitus, diabetes insipidus and weight gain. Review article describes typical hormonal and metabolic dysfunctions, their prevalence, risk factors, possible mechanisms, monitoring and treatment.
Address for correspondence:Dominik Strzelecki
Klinika Zaburzeń Afektywnych
Centralny Szpital Kliniczny Uniwersytetu Medycznego
92-216 Łódź, ul. Czechosłowacka 8/10
tel. (042)6757371, fax. (042)6757403
e-mail:
strzeleckidomin@poczta.onet.pl