2003 issue 4


Volume 19, issue 4


Increased serum levels of immune complexes (IC) and the presence of antigens of Chlamydia pneumoniae and Cytomegalovirus in IC in patients with ischemic stroke

Beata Tarnacka1, Grażyna Gromadzka1,2, Anna Członkowska1,2
1. II Klinika Neurologii Instytutu Psychiatrii i Neurologii w Warszawie; Zakład Elektrofizjologii Instytutu Psychiatrii i Neurologii w Warszawie
2. Zakład Farmakologii Klinicznej i Doświadczalnej Akademii Medycznej w Warszawie
Farmakoterapia w Psychiatrii i Neurologii, 2003, 4, 21-39
Keywords: Chlamydia pneumoniae, Cytomegalovirus, immune complex, ischemic stroke


The mechanisms of immune reaction involved in the pathogenesis and clinical course of acute vascular incidents are still not completely understood. The aim of this study was to examine the presence of immune complexes (IC) in the acute stroke setting and the first month thereafter and to characterize IC by analyzing the contents of chlamydial lipopolysaccharide and anti-cytomegalovirus (CMV) antibodies in IC.
Serum concentration of IC was investigated in 179 stroke patients, 122 "old" controls and 112 "young" controls, by the precipitation method. The presence of chlamydial lipopolisaccharyde and anti-CMV antibodies was investigated in some IC preparations by the ELISA method after earlier dissociation of IC into components by high pH treatment.
Significantly increased serum Je concentration in stroke patients was noticed. Increased serum IC concentration was revealed as an independent strong stroke risk factor and was connected with significantly worse neurological status and increased 30-day mortality rate. A significantly larger proportion of stroke patients than controls had Chlamydia pneumoniae antigen and anti-CMV antibodies in IC.
This study provides the first evidence of an association between increased serum level of IC and the clinical course of cerebral ischemia and identifies a potentially important association of C. pneumoniae and CMV-specific IC with stroke incidence.