2003 issue 4


Volume 19, issue 4


8-Hydroxy-2’-deoxyguanosine in neurodegenerative diseases of aged

Jolanta Dorszewska1, Zofia Adamczewska-Goncerzewicz1, Wojciech Kozubski2, Jolanta Florczak2
1. Zakład Neurochemii Klinicznej Katedry Neurologii Akademii Medycznej w Poznaniu
2. Katedra i Klinika Neurologii Akademii Medycznej w Poznaniu
Farmakoterapia w Psychiatrii i Neurologii, 2003, 4, 41-48
Keywords: Alzheimer disease, Parkinson’s disease, HPLC, 8-oxo2dG


The aim of the study was to reveal the systematic structural changes in Alzheimer disease (AD) and Parkinson’s disease (PD).
8-oxo-2’-deoxyguanosine (8-oxo2dG) a marker of oxidative stress in DNA was measured in lymphocytes of AD and PD patients, and healthy controls using HPLC/EC/UV (high-pressure liquid chromatography with electrochemical and UV detections).
The content of 8-oxo2dG in lymphocytes of AD and PD patients was significantly higher than in age-matched controls. The increase of 8-oxo2dG content in the group aged 24-64 years was statistically insignificant.