Ginkgo biloba extracts such as EGb-761 have been suggested to have a multitude of beneficial effects on brain function, from enhancing cognitive function in dementia. Several mechanisms of action are useful in explaining how EGb 761 benefits patients with AD and other age-related, neurodegenerative disorders. The EGb 761 possesses antioxidant and free radical-scavenging activities and inhibits membrane lipid peroxidation. Flavonoids purchased from EGb 761 may inhibit the monoaminooxidase activity in brain and they increase the respiratory control ratio of brain mitochondria. EGb 761 is useful drug in dementia and other neurodegenerative diseases.