2001 issue 2


Volume 17, issue 2


Transporter serotoniny

Urszula Pych1, Anna Tonderska1, Andrzej Bidziński1, Adam Płaźnik1
1. Zakład Neurochemii Instytutu Psychiatrii i Neurologii w Warszawie; Katedra i Zakład Farmakologii Doświadczalnej i Klinicznej Akademii Medycznej w Warszawie
Farmakoterapia w Psychiatrii i Neurologii, 2001, 2, 175-198


The termination or serotoninergic neurotransmission is accomplished by rapid uptake or the released 5-HT by serotonin transporter (5-HTT). Activity 5-HIT is regulated by kinase C and phosphatase 2A. Changes in peripheral and central activity of 5-HIT (its uptake kinetic, Vmax and Km) are intensively studied. Many reports show modification in the binding of platelet presynaptic 5-HT uptake sites in psychiatric illnesses (with [3H]imipramine, [3H]paroxetine, [3H]citalopram used as ligands). This papers reviews some of the most important data from this field of research.