Abstract
The comparison of anxiety models used in animals to clinical syndromes of anxiety and stress is difficult, because the evaluation of emotional states of animals is subjective and prone to differing interactions.
The experimental models of anxiety can be divided depending on the method used into Punishment Induced Suppression Tests and Novelty Induced Inhibition. The Two Compartment Exploratory Test of Crawley has proved to be a very sensitive test for drugs with different action mechanisms and confirmed usefulness in human anxiety diseases.