1998 issue 3


Volume 14, issue 3


Terapia monitorowana depresji

Maria Radziwon-Zaleska1, Halina Matsumoto1, Michał Skalski1, Wojciech Androsiuk1, Anna Dziklińska1, Iwona Grobel1, Paweł Kunicki1
1. I Klinika Psychiatryczna Akademii Medycznej w Warszawie; Zakład Biochemii Instytutu Kardiologii w Warszawie-Aninie
Farmakoterapia w Psychiatrii i Neurologii, 1998, 3, 5-12


Therapeutic monitoring of depression is a method aiming at the optimalization of pharmacotherapy, serving to enlarge the efficacy and safety of pharmacotherapy in an individual case of illness. The application of modern monitoring techniques, such as: precise clinical assessment, determination of tricyclic antidepressant (TCA) concentration in blood or assessment of phenotype of hydroxylation enable the optimalization of therapy focused on a specific patient. On the example of therapy applied to 32 patients treated with TCA in major depression, a trial was taken up to analyse the obtained results, considering the eventual prognostic factors.