During l year in 348 schizophrenic patients the therapy with 6 depot neuroleptics (haloperidol, flupenthixol, fluphenazine, perphenazine, pipothiazine, zuklopenthixol) were provided. Psychopathological state (BPRS, CGI, AMDP), adverse events (ARI, SOZP) and social functioning (SAI) were evaluated. Full remission was observed in 49% of the patients. In group of 209 patients the effect of therapy with different neuroleptics was compared during l year medication. These results suggest that the therapy with neuroleptics with high affinity to the serotoninergic receptor companied few severe extrapyramidal symptoms (fluphenazine, flupenthixol). The neuroleptics with D1, alfa-l-adrenergic blocking and antihistaminic activity caused marked sedation in patients (zuklopenthixol, fluphenazine).